ABSTRACT
Breast cancer is the first cancer in women. Lymphatic involvement in breast cancer is common, especially in our patients because of the frequency of locally advanced forms. This contrast with a weak rate of diagnosed internal mammary chain invasion. To clarify the atypical presentations of internal mammary chain involvement in breast cancer. We present observations of patients presenting atypical forms of internal mammary chain involvement. The invasion of internal mammary chain is often underestimated. Indeed, this site of lymphatic spread is not accessible to the clinical exam and its radiological exploration is not systematic. Otherwise, different clinical, pathological and radiological presentations have to attract our attention to a potential internal mammary chain invasion. Our misrecognition of this site of spread and its different presentations can partly explain the lack of diagnosis
ABSTRACT
Tumor cells express surface structures different from normal cells. These structures may be recognized by the immune system, which ensure anti-tumoral surveillance. Antigenic presentation requires HLA molecules role. Since, these molecules are encoded by a high polymorphic system, immune response can be modulated according to HLA genotype. So, HLA polymorphism could be correlated with tumor escape from anti-tumor immunosurveillance. We have aimed to search for possible associations between HLA DQB 1 alleles and the histoprognostical parameters in breast cancer in the Tunisian population. DQB 1 alleles were determined by PCR-SSO molecular typing in 100 healthy matched and unrelated Tunisian female and 87 Tunisian women with breast cancer. Allelic distribution between the two studied groups showed no significant associations between this locus and the occurrence, the EE grade and the lymph node invasion of breast cancer in the Tunisian population. This result may be explained by the fact that cancer is a multifactoral disease due to several interacting factors that might change from one population to another
Subject(s)
Humans , Female , HLA-DQ Antigens , Breast Neoplasms/pathology , Prognosis , Genotype , Alleles , Polymorphism, GeneticABSTRACT
The internal mammary nodes are often underestimated as breast cancer lymphatic pathway spread. It is yet the first site of lymphatic invasion in central or internal tumors and the second site in external tumors. The intra-thoracic situation of internal mammary nodes explains partly, the difficulty of its exploration. To evaluate the risk of internal mammary node invasion, some predictive factors are established [tumor size, internal or central tumor location, axillary node invasion and young age]. Prognostic and therapeutic impact of invasion justifies its systematic research. Without exploring internal mammary nodes status, TNM classification remains, incomplete. CT scanner, magnetic resonnance imaging, positron emission tomography scanner and sentinel node exploration technique are helpful to explore this region and to adapt its irradiation
Subject(s)
Humans , Lymph Nodes , Breast Neoplasms/classification , Breast Neoplasms/therapyABSTRACT
The aim of this study was to determine the clinical and epidemiological aspects of skin cancer in Tunisia. We analysed the clinical files of all cases of skin cancer registrated at the ISA institute between 1975 and 1984. 1379 cases of skin cancer were referred to ISA, representing 9.02%of all cancer cases referred to the institute during the same period. Basal cell carcinoma [CBC] was the most frequent type [57.5%] followed by squamous cell carcinoma [CSC]: 32.6%and melanomas: 4%. The sex ratio was 1.7 with a mean age of 61 years in men and 60 years in women. The face was the most frequent involved sites in CBC [92%]. This region is usually exposed to the sun. The distribution of CSC in the body was different. The lesions were multiple in 11%of the cases. 13.7%of the CSC were developped on a burn scar. 21 cases were radio-induced and 45 patients had a xeroderma pigmentosum. Skin cancer is relatively frequent in Tunisia. However, our incidence is inferior to other countries. Sun exposure is the main risk factor
Subject(s)
Humans , Male , Female , Retrospective Studies , Risk Factors , Skin Neoplasms/pathology , Xeroderma PigmentosumABSTRACT
The vast majority of primary vaginal cancers are squamous cell carcinoma. The leiomyosarcoma of the vagina is extremely rare neoplasm. It comprising 2% to 3% of vaginal malignancies. Only 77 cases have been reported up to date in Anglo-Saxon literature. Report of a new case. We report a case of a patient 43 years old, single and presented a tumor of 7 cm to the detriment of the posterior wall of the vagina. The treatment consisted of a radical colpohysterectomy followed by postoperative radiotherapy. After 40 months, she is still alive without local or distant recurrence. This is a rare observation. The surgery is the basic treatment, the poor prognosis of these tumors remains linked especially to the histological grade
Subject(s)
Humans , Female , Vaginal Neoplasms/pathology , Leiomyosarcoma/surgery , Prognosis , ReviewABSTRACT
Multiple primary malignant neoplasm in a single patient have been well documented in the literature. The lesions can be limited to a single organ or involve multiple organ systems and can be synchronous or metachronous. Report of a new case. We report the case of a 63 year old women with a rectocolonic carcinoma; during surgery an ileal nodule was discovered also as liver metastasis. The final pathologic report on the specimen revealed an adenocarcinoma of the colon and a carcinoid tumor of the small bowel with liver metastasis. Tumoral association is relatively common for patients with small intetinal carcinoids. The association carcinoide of hail with primitive tumour not carcinoide is reported primarily with carcinomes of the digestive tract in particulary recto colics carcinoma
ABSTRACT
This is a retrospective study of patients treated for cancer cervix staged IB2, IIA or lIB with bulky tumor [>4cm]. Treatment was concurrent radiotherapy [45Gy with I,8Gy daily fraction] and chemotherapy [5 cycles of Platinum 40mg/m2/week]. All patients. underwent Brachytherapy [l5Gy on the reference isodose according to Paris system] followed by surgery [radical abdominal hysterectomy and bilateral pelvic lymphadenectomy: Piver 3]. Between October 1999 and December 2002, forty five patients were treated in this protocol. Median age was 46 years [21- 68]. Histology was squamous cell carcinoma in 93% and glandular carcinoma in 7%. Average external radiation dose was 44Gy [20-50]. Ninety three% of patients had at least 3 cycles of chemotherapy and 46,5% received the planned 5 cycles. On the operative specimens, there was 62,5% complete response and only 7 pelvic node involvement [17,5%]. Four postoperative complications were noted [one vascular injury, one urinary fistula, one phlebitis and one lymph collection]. Preoperative combined radiotherapy and chemotherapy in the early bulky stages of uterine cervix cancer is well tolerated and "gives" a high rate of sterilisation. There was no increase in surgical morbidity
Subject(s)
Humans , Female , Uterine Cervical Neoplasms/drug therapy , Radiotherapy , Antineoplastic AgentsABSTRACT
Very late metastases after cancer therapy are not common. We report an exceptional case of breast carcinoma associated with pregnancy that reocurred in the form of brain metastasis 49 years after initial treatment